WebTo enable predictive modeling in pediatrics, celecoxib pharmacokinetics were standardized using allometry. Results: Movement of all three unbound plasma COX-2 drugs into CSF was characterized by a common equilibration half-time (T 1/2 keq) of 0.84 h. Influx was faster than efflux and a transfer scaling factor of 2.01 was required to describe ... WebFor example, if a large animal is included in the scaling, the predicted clearance in a large animal should be considered overestimated if the exponent of simple allometry is >1.3. Despite the potential for extrapolation error, the reality is that allometric scaling is needed across many veterinary practice situations, and therefore will be used.
Systems Free Full-Text A Sceptics View: “Kleiber’s Law” or the …
WebResearch Scientist. Jan 2009 - Dec 20168 years. Houston, Texas. • Developed novel algorithms for modeling turbidite-lobe reservoirs (Matlab/C-MEX prototype). Worked with … WebApr 28, 2014 · Allometry, the technique previously used to empirically analyse relative growth, showed BMR of endotherms varied with 0.73–0.74 power of body mass. Kleiber suggested that mass3/4 be used, partly because of its easy calculation with a slide rule. Later studies have produced a range of BMR scaling exponents, depending on species … charity and philanthropy for dummies
Allometry - an overview ScienceDirect Topics
WebSep 30, 2012 · Vertical allometry was first described by Calder, who explained the larger human BW (3.5 times more than the predicted BW by allometric scaling) as a special capability of adaptation. Some examples of compounds that exhibit vertical allometry include diazepam, warfarin, valproic acid and tamsulosin, as the predicted clearances … Weballometry: (ə-lŏm′ĭ-trē) n. 1. The disproportionate growth of a part or parts of an organism as the organism changes in size. 2. The study of such growth. al′lo·met′ric (ăl′ə-mĕt′rĭk) adj. WebThe meaning of ALLOMETRY is relative growth of a part in relation to an entire organism or to a standard; also : the measure and study of such growth. relative growth of a part in … charity and philanthropy