WebSterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded … WebApr 12, 2024 · In Fig. 2a, the rabbit polyclonal anti-SREBP1 antibody (Proteintech 14088-1-AP) and the mouse mAb (BD Bioscience, 557037) were used for detecting SREBP1 and SREBP2, respectively, while the rabbit ...
Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr …
WebThis review provides new insights into SREBP as a mediator of kidney fibrosis via lipid-independent pathways. Skip to main ... synthesis in lipogenic organs, such as the liver. In … WebIn addition, endogenous SREBP2–SCAP complexes were immunoprecipitated with a mouse anti-SREBP2 antibody that recognizes both the full-length and cleaved C-terminal portion of SREBP2 ... Activation of the SCAP–SREBP2 pathway in response to PDE4+8 inhibition … giant\u0027s kinship
IJMS Free Full-Text Targeting the SREBP-1/Hsa-Mir …
WebJan 21, 2024 · Director, Cell Line Engineering. Jan 2024 - Present4 months. New York, New York, United States. Cell line engineering for target validation, mechanistic studies and lead development @ Discovery ... WebMar 28, 2013 · In contrast hepatic tissue ChREBP activity was reduced in NS excluding its role in upregulation of FA synthetic pathway. ... This was accompanied by increased protein abundance of Insig-1 and SCAP ... groups. H. Representative western blots and group data depicting nuclear abundance of hepatic tissue SREBP2 in the nephrotic (NS ... WebJan 5, 2024 · This finding is consistent with an increased TC content (Figure 5A) and is in line with previous studies [64,65], suggesting that 1.0% analogue stimulates the cholesterol synthesis in the fatty acid-induced HepG2 cells, likely through the SCAP-SREBP2 pathway by lowering free cholesterol in the cells and/or desensitizing SCAP to cholesterol . frozen pizza thawed in freezer